PUBLICATIONS

MULTI-LAYERED GENOME DEFENCES IN BACTERIA

Current Opinion in Microbiology (2024) 78: 102436

Agapov A., Baker K.S., Bedekar P., Bhatia R.P., Blower T.R., Brockhurst M.A., Brown C., Chong C.E., Fothergill J.L., Graham S., Hall J.P.J., Maestri A., McQuarrie S., Olina A., Pagliara S., Recker M., Rochmond A., Shaw S.J., Szczelkun M.D., Taylor T.B., van Houte S., Went S.C., Westra E.R., White M.F. & Wright R.

TOXIN RELEASE BY CONDITIONAL REMODELLING OF PARDE1 FROM MYCOBACTERIUM TUBERCULOSIS LEADS TO GYRASE INHIBITION

Nucleic Acids Research (2023) 52: 1909-1929

Beck I.N., Arrowsmith T.J., Grobbelaar M.J., Bromley E.H.C., Marles-Wright J. & Blower T.R.

VIRUSES WRAP UP BACTERIAL DEFENCE SYSTEMS

Nature (2023) 10.1038/d41586-023-03796-8

Blower T.R. & van Houte S.

USING ENERGY TO GO DOWNHILL - A GENOPROTECTIVE ROLE FOR ATPASE ACTIVITY IN DNA TOPOISOMERASE II

Nucleic Acids Research (2023) 52: 1313-1324

Bandak A.F.*, Blower T.R.*, Nitiss K.C., Shah V., Nitiss J.L. & Berger J.M.

DIVERSE DURHAM COLLECTION PHAGES DEMONSTRATE COMPLEX BREX DEFENSE RESPONSES

Applied and Environmental Microbiology (2023) 00623-23

Kelly A.*, Went S.C.*, Mariano G., Shaw L.P., Picton D.M., Duffner S.J., Coates I., Herdman-Grant R., Gordeeva J., Drobiazko A., Isaev A., Lee Y-J., Luyten Y., Morgan R.D., Weigele P., Severinov K., Wenner N., Hinton J.C.D. & Blower T.R.

MENT NUCLEOTIDYLTRANSFERASE TOXINS EXTEND TRNA ACCEPTOR STEMS AND CAN BE INHIBITED BY ASYMMETRICAL ANTITOXIN BINDING

Nature Communications (2023) 12: 4644

Xu X.*, Usher B.*, Gutierrez C., Barriot R., Arrowsmith T.J., Han X., Redder P., Neyrolles O., Blower T.R.† & Genevaux P.†

NATURALLY MUTAGENIC SEQUENCE DIVERSITY IN A HUMAN TYPE II TOPOISOMERASE

PNAS (2023) 120: e2302064120

Bandak A.F., Blower T.R., Nitiss K.C., Gupta R., Lau A.Y., Guha R., Nitiss J.L. & Berger J.M.

THE NOVEL ANTI-PHAGE SYSTEM SHIELD CO-OPTS AN RMUC DOMAIN TO MEDIATE PHAGE DEFENSE ACROSS PSEUDOMONAS SPECIES

PLoS Genetics (2023) 19: e1010784

Macdonald E., Wright R., Connolly J.P.R., Strahl H., Brockhurst M., van Houte S., Blower T.R., Palmer T. & Mariano G.

TOXIN-ANTITOXIN SYSTEMS AS MEDIATORS OF PHAGE DEFENCE AND THE IMPLICATIONS FOR ABORTIVE INFECTION

Current Opinion in Microbiology (2023) 73: 102293

Kelly A., Arrowsmith T.J., Went S.C. & Blower T.R.

CONSERVED DOMAINS CAN BE FOUND ACROSS DISTINCT PHAGE DEFENCE SYSTEMS

Molecular Microbiology (2023) 120(1): 45-53

Mariano, G.* & Blower T.R.

ALLOPHYCOCYANIN A IS A CARBON DIOXIDE RECEPTOR IN THE CYANOBACTERIAL PHYCOBILISOME

Nature Communications (2022) 13: 5289

Guillen-Garcia A., Gibson S., Jordan C., Ramaswamy V., Linthwaite V., Hodgson D., Blower T.R., Verlet J., Degiacomi M., Palsson L-O. & Cann M.J.

CRYSTAL STRUCTURE OF THE BREX PHAGE DEFENCE PROTEIN BRXA

Current Research in Structural Biology (2022) 4: 211-219

Beck I.N., Picton D.M. & Blower T.R.

A COMPREHENSIVE STRUCTURAL ANALYSIS OF THE ATPASE DOMAIN OF HUMAN DNA TOPOISOMERASE II BETA BOUND TO AMPPNP, ADP, AND THE BISDIOXOPIPERAZINE, ICRF193

Structure (2022) 30(8): 1129-1145.e3

Ling E.M., Baslé A., Cowell I.G., van den Berg B., Blower T.R. & Austin C.A.

A WIDESPREAD FAMILY OF WYL-DOMAIN TRANSCRIPTIONAL REGULATORS CO-LOCALIZES WITH DIVERSE PHAGE DEFENCE SYSTEMS AND ISLANDS

Nucleic Acids Research (2022) 50(9): 5191–5207

Picton D.M., Harling-Lee J.D., Duffner S.J., Went S.C., Morgan R.D., Hinton J.C.D. & Blower T.R.

THE PHAGE DEFENCE ISLAND OF A MULTIDRUG RESISTANT PLASMID USES BOTH BREX AND TYPE IV RESTRICTION FOR COMPLEMENTARY PROTECTION FROM VIRUSES

Nucleic Acids Research (2021) 49(19): 11257-11273

Picton D.M., Luyten Y.A., Morgan R.D., Nelson A., Smith D.L., Dryden D.T.F., Hinton J.C.D. & Blower T.R.

CRYSTAL STRUCTURE OF THE ANTI-CRISPR REPRESSOR ACA2

Journal of Structural Biology (2021) 213(3): 107752

Usher B., Birkholz N., Beck I.N., Fagerlund R.D., Jackson S.A., Fineran P.C. & Blower T.R.

ISOLATION AND CHARACTERISATION OF BACTERIOPHAGES WITH ACTIVITY AGAINST INVASIVE NON-TYPHOIDAL SALMONELLA CAUSING BLOODSTREAM INFECTION IN MALAWI

Viruses (2021) 13(3): 478

Rodwell E.V., Wenner N., Pulford C.V., Cai Y., Bowers-Barnard A., Beckett A., Rigby J., Picton D.M., Blower T.R., Feasey N.A., Hinton J.C.D. & Perez-Sepulveda B.M.

A NUCLEOTIDYLTRANSFERASE TOXIN INHIBITS GROWTH OF MYCOBACTERIUM TUBERCULOSIS THROUGH INACTIVATION OF TRNA ACCEPTOR STEMS

Science Advances (2020) 6(31): eabb6651

Cai Y.*, Usher B.*, Gutierrez C., Tolcan A., Mansour M., Fineran P.C., Condon C., Neyrolles O., Genevaux P.† & Blower T.R.†

ANTITOXIN AUTOREGULATION OF M. TUBERCULOSIS TOXIN-ANTITOXIN EXPRESSION THROUGH NEGATIVE COOPERATIVITY ARISING FROM MULTIPLE INVERTED REPEAT SEQUENCES

Biochemical Journal (2020) 477(12): 2401-2419

Beck I.N., Usher B., Hampton H.G., Fineran P.C. & Blower T.R.

ANTICANCER RUTHENIUM COMPLEXES WITH HDAC ISOFORM SELECTIVITY

Molecules (2020) 25(10): 2383

Cross J.M., Blower T.R., Kingdon A.D.H., Pal R., Picton D.M. & Walton J.W.

A COMPLEX SUITE OF LOCI AND ELEMENTS IN EUKARYOTIC TYPE II TOPOISOMERASES DETERMINE SELECTIVE SENSITIVITY TO DISTINCT POISONING AGENTS

Nucleic Acids Research (2019) 47(15): 8163-8179

Blower T.R., Bandak A., Lee A.S.Y., Austin C.A., Nitiss J.L. & Berger J.M.

ABIEI BINDS COOPERATIVELY TO THE TYPE IV ABIE TOXIN-ANTITOXIN OPERATOR VIA A POSITIVELY-CHARGED SURFACE AND CAUSES DNA BENDING AND NEGATIVE AUTOREGULATION

Journal of Molecular Biology (2018) 430(8): 1141-1156

Hampton H.G., Jackson S.A., Fagerlund R.D., Vogel A.I.M., Dy R.L., Blower T.R. & Fineran P.C.

MECHANISM OF ACTION OF MYCOBACTERIUM TUBERCULOSIS GYRASE INHIBITORS: A NOVEL CLASS OF GYRASE POISONS

ACS Infectious Diseases (2018) 4(8): 1211-1222

Gibson E.G., Blower T.R., Cacho M., Bax B., Berger J.M. & Osheroff N.

EVOLUTION OF PECTOBACTERIUM BACTERIOPHAGE ΦM1 TO ESCAPE TWO BIFUNCTIONAL TYPE III TOXIN-ANTITOXIN AND ABORTIVE INFECTION SYSTEMS THROUGH MUTATIONS IN A SINGLE VIRAL GENE

Applied and Environmental Microbiology (2017) 83(8): e03229-16

Blower T.R., Chai R., Przybilski R., Chindhy S., Fang X., Kidman S.E., Tan H., Luisi B.F., Fineran P.C. & Salmond G.P.C.

RECOGNITION OF DNA SUPERCOIL GEOMETRY BY MYCOBACTERIUM TUBERCULOSIS GYRASE

Biochemistry (2017) 56(40): 5440-5448

Ashley R.E., Blower T.R., Berger J.M. & Osheroff N.

ANTICANCER RUII AND RHIII PIANO-STOOL COMPLEXES THAT ARE HISTONE DEACETYLASE INHIBITORS

ChemPlusChem (2016) 81(12): 1276-1280

Cross J.M., Blower T.R., Gallagher N., Gill, J.H., Rockley K.L. & Walton J.W.

CRYSTAL STRUCTURE AND STABILITY OF GYRASE–FLUOROQUINOLONE CLEAVED COMPLEXES FROM MYCOBACTERIUM TUBERCULOSIS

Proceedings of the National Academy of Sciences of the United States of America (2016) 113(7): 1706-1713

Blower T.R., Williamson B.H., Kerns R.J. & Berger J.M.

FLUOROQUINOLONE INTERACTIONS WITH MYCOBACTERIUM TUBERCULOSIS GYRASE: ENHANCING DRUG ACTIVITY AGAINST WILD-TYPE AND RESISTANT GYRASE

Proceedings of the National Academy of Sciences of the United States of America (2016) 113(7): E839-E846

Aldred K.J., Blower T.R., Kerns R.J., Berger J.M. & Osheroff N.

CO-EVOLUTION OF QUATERNARY ORGANIZATION AND NOVEL RNA TERTIARY INTERACTIONS REVEALED IN THE CRYSTAL STRUCTURE OF A BACTERIAL PROTEIN–RNA TOXIN–ANTITOXIN SYSTEM

Nucleic Acids Research (2015) 43(19): 9529-9540

Rao F., Short F.L., Voss J.E., Blower T.R., Orme A.L., Whittaker T.E., Luisi B.F. & Salmond G.P.C.

IDENTIFICATION AND CLASSIFICATION OF BACTERIAL TYPE III TOXIN-ANTITOXIN SYSTEMS ENCODED IN CHROMOSOMAL AND PLASMID GENOMES

Nucleic Acids Research (2012) 40(13): 6158-6173

Blower T.R., Short F.L., Rao F., Mizuguchi K., Pei X.Y., Fineran P.C., Luisi B.F. & Salmond G.P.C.

VIRAL EVASION OF A BACTERIAL SUICIDE SYSTEM BY RNA-BASED MOLECULAR MIMICRY ENABLES INFECTIOUS ALTRUISM

PLoS Genetics (2012) 8(10): e1003023

Blower T.R., Evans T.J., Przybilski R., Fineran P.C. & Salmond G.P.C.

VIRAL MOLECULAR MIMICRY CIRCUMVENTS ABORTIVE INFECTION AND SUPPRESSES BACTERIAL SUICIDE TO MAKE HOSTS PERMISSIVE FOR REPLICATION

Bacteriophage (2012) 2(4): 234-238

Blower T.R., Short F.L., Fineran P.C. & Salmond G.P.C.

BALANCING AT SURVIVAL'S EDGE: THE STRUCTURE AND ADAPTIVE BENEFITS OF PROKARYOTIC TOXIN-ANTITOXIN PARTNERS

Current Opinion in Structural Biology (2011) 21(1): 109-18

Blower T.R., Salmond G.P.C. & Luisi B.F.

A PROCESSED NON-CODING RNA REGULATES AN ALTRUISTIC BACTERIAL ANTIVIRAL SYSTEM

Nature Structural and Molecular Biology (2011) 18(2): 185-190

Blower T.R., Pei X.Y., Short F.L., Fineran P.C., Humphreys D.P., Luisi B.F. & Salmond G.P.C.

MUTAGENESIS AND FUNCTIONAL CHARACTERISATION OF THE RNA AND PROTEIN COMPONENTS OF THE TOXIN ABORTIVE INFECTION AND TOXIN-ANTITOXIN LOCUS OF ERWINIA

Journal of Bacteriology (2009) 191(19): 6029-6039

Blower T.R., Fineran P.C., Johnson M.J., Toth I.K., Humphreys D.P. & Salmond G.P.C.

THE PHAGE ABORTIVE INFECTION SYSTEM, TOXIN, FUNCTIONS AS A PROTEIN-RNA TOXIN-ANTITOXIN PAIR

Proceedings of the National Academy of Sciences of the United States of America (2009) 106(3): 894-899

Fineran P.C., Blower T.R., Foulds I.J., Humphreys D.P., Lilley K.S. & Salmond G.P.C.